The Wellcome Foundation/World Health Organisation Onchocerciasis Chemotherapy Project Joint Programme to discover and develop a macrofilaricide for onchocerciasis.

摘要: The primary objective of the Wellcome Foundation/World Health Organisation Onchocerciasis Chemotherapy Project, which began in July 1982, was discovery and development a safe effective macrofilaricide for treatment onchocerciasis man. A multidisciplinary Team biologists, biochemists medicinal chemists assembled. They investigated variety potential targets filariae carried out in-depth lead optimisation studies on number different chemical series. valuable contribution made to our understanding filarial biology biochemistry susceptibility various metabolic inhibitors. However, ultimate goal identification compound worthy evaluation man not achieved programme closed at end June 1989. Factors that contributed this situation some overall conclusions are discussed.