Unresolved issues in anthelmintic pharmacology for helminthiases of humans.

摘要: Helminth infections are an important constraint on the health and development of poor children adults. Anthelmintic treatment programmes provide a safe effective response, increasing numbers people benefitting from these public initiatives. Despite decades clinical experience with anthelmintics for human infections, relatively little is known about their pharmacology. All drugs were developed initially in response to considerable market veterinary high- middle-income countries. In contrast, greatest burden caused by humans resource-poor settings as result there has been insufficient commercial incentive support studies how work humans, they should best be used control programmes. The advent mass drug administration schistosomiasis, lymphatic filariasis, onchocerciasis soil-transmitted helminthiases increases urgency better understand monitor resistance, broaden currently very narrow range available anthelmintics. This provides fresh impetus developing comprehensive research platform designed improve our understanding drugs, order bring scientific knowledge base supporting use standard equivalent that commonly Furthermore, pharmacology will enable improved therapy could contribute discovery new products.