The neurobiology of aggression: implications for the pharmacotherapy of aggressive challenging behaviour by people with intellectual disabilities.

摘要: Aim The aim of this review is to summarise current understanding the neurobiology aggression and within context consider evidence base for pharmacotherapy aggressive challenging behaviour by people with intellectual disabilities (ID). Evidence Aggressive encounters involve a variety psychological processes progress has been made in brain mechanisms involved. However, role neurotransmitters serotonin, dopamine γ-aminobutyric acid no longer as clear it once appeared, result that predictions cannot be confidence about drug effects on aggression. There have relatively few controlled trials ID, or, indeed, general population, their outcomes largely negative. Conclusion With possible exception risperidone, there reliable antidepressant, neuroleptic or anticonvulsant drugs are effective treatments ID.