Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis

摘要: In a double-blind, randomized, multicentre clinical study, the efficacy and tolerance of herbal medicine product, Harpadol (6 capsules/day, each containing 435 mg powdered cryoground powder Harpagophytum procumbens), was compared with diacerhein 100 mg/day in treatment, for 4 months, 122 patients suffering from osteoarthritis knee hip. Assessments pain functional disability were made on 10 cm horizontal visual analogue scale; severity evaluated by Lequesne's index. Spontaneous showed significant improvement during course study there no difference two treatments. Similarly, progressive reduction Lequesne index statistical found between diacerhein. At completion taking using significantly less NSAIDs antalgic drugs. The frequency adverse events lower group. most frequent event reported diarrhea, occurring 8.1% 26.7% respectively. global assessment at end treatment favoured Harpadol. results this demonstrate that is comparable superior safety to