Expression of programmed cell death-ligand 1 and its correlation with clinical outcomes in gliomas

摘要: Programmed cell death-ligand 1(PD-L1) was expressed in various malignancies, and interaction with its receptor programmed death 1 (PD-1) often contributed to immune evasion of tumor cells. In this study, we explored the expression PD-L1 correlation clinical outcomes gliomas. Clinicopathological data 229 patients gliomas collected. assessed by tissue-microarray-based immunohistochemistry. Over 5% cells cytoplasm or membrane staining defined as positive expression. The associations clinicopathological features overall survival (OS) disease-free (DFS) were analyzed univariate analysis multivariate further performed Cox regression model. observed 51.1% no significant association verified between pathological grade patients. However, rate 49.2%, 53.7% 68.8% for II, III IV 161 those ≥ 12 months OS, respectively. Although discrepancies displayed, there a certain degree differences (49.2% vs. 68.8%, P = 0.327). Univariate showed that significantly associated poor OS long-time follow up (OS months) (P 0.018), especially 0.019). Multivariate revealed strong tendency towards statistical significance found 0.081). up, could indicate prognosis it is possible immunotherapy targeting pathway needed be determined study.