Expression and prognostic role of orphan receptor GPR110 in glioma.
作者： Haiping Shi , Shiyuan Zhang
DOI: 10.1016/J.BBRC.2017.07.097
关键词:
摘要: Glioma is the most common type of malignancy in central nervous system, which has a poor prognosis due to its rapid progression and diffuse invasion. Identification novel biomarkers for glioma would be invaluable studying disease mechanism improving prognosis. Orphan G protein-coupled receptor 110 (GPR110) belongs subfamily VI adhesion GPCR. The knowledge ligand, signaling pathway or physiology function GPR110 poorly elucidated. potential role as an oncogene mouse been recently reported by mutagenesis screen. However, expression human hasn't identified. Here current study, we initially explored RNA protein patients with glioma. Statistical analysis proved that was highly expressed some patients, correlated advanced stages. Furthermore, univariate multivariate analyses revealed independent prognostic biomarker overall survival patients. Interestingly, cellular studies showed overexpression knockdown U87 cells didn't affect cell proliferation migration. invasion significantly enhanced GPR110-overepxression, while inhibited GPR110-knockdown. detailed mechanisms remain further investigation although our results suggested possible participation STAT3 instead ERK pathways.
sci-hub.se 参考文章(24)
John P. Overington, Bissan Al-Lazikani, Andrew L. Hopkins, How many drug targets are there Nature Reviews Drug Discovery. ,vol. 5, pp. 993- 996 ,(2006) , 10.1038/NRD2199
James E Darnell, Validating Stat3 in cancer therapy Nature Medicine. ,vol. 11, pp. 595- 596 ,(2005) , 10.1038/NM0605-595
Adit Ben-Baruch, Organ selectivity in metastasis: regulation by chemokines and their receptors Clinical & Experimental Metastasis. ,vol. 25, pp. 345- 356 ,(2008) , 10.1007/S10585-007-9097-3
Robert Fredriksson, Malin C Lagerström, Pär J Höglund, Helgi B Schiöth, Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions FEBS Letters. ,vol. 531, pp. 407- 414 ,(2002) , 10.1016/S0014-5793(02)03574-3
Vivian Wai Yan Lui, Sufi Mary Thomas, Qing Zhang, Abbey Lynn Wentzel, Jill Marie Siegfried, Joyce Yan Li, Jennifer Rubin Grandis, Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor. Oncogene. ,vol. 22, pp. 6183- 6193 ,(2003) , 10.1038/SJ.ONC.1206720
Hannah M. Stoveken, Alexander G. Hajduczok, Lei Xu, Gregory G. Tall, Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 112, pp. 6194- 6199 ,(2015) , 10.1073/PNAS.1421785112
Patrick Y. Wen, Santosh Kesari, Malignant Gliomas in Adults The New England Journal of Medicine. ,vol. 359, pp. 492- 507 ,(2008) , 10.1056/NEJMRA0708126
Meike Burger, Tanja Hartmann, Jan A Burger, Ingrid Schraufstatter, KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway Oncogene. ,vol. 24, pp. 2067- 2075 ,(2005) , 10.1038/SJ.ONC.1208442
Hua Yu, Drew Pardoll, Richard Jove, STATs in cancer inflammation and immunity: a leading role for STAT3 Nature Reviews Cancer. ,vol. 9, pp. 798- 809 ,(2009) , 10.1038/NRC2734
Amy M Lum, Bruce B Wang, Gabriele B Beck-Engeser, Lauri Li, Namitha Channa, Matthias Wabl, Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer BMC Cancer. ,vol. 10, pp. 40- 40 ,(2010) , 10.1186/1471-2407-10-40