Significance of the 13 C-caffeine breath test for patients with cirrhosis

作者: George V. Papatheodoridis , Ekaterini Margariti , Emilia Hadziyannis , Dimitrios Konstantinou , Dimitrios Pectasides

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摘要: Background The 13C-caffeine breath test (CBT) is a non-invasive, quantitative of liver function which has been shown to correlate inversely the Child-Pugh score. aim study was determine utility CBT in assessment cirrhosis and its correlation model for end-stage disease (MELD) Methods Thirty-nine patients, 29 with 10 chronic without cirrhosis, 8 healthy volunteers were included. Cirrhotic patients graded according MELD scores. All participants underwent laboratory tests on same day. results expressed as percentages changes over baseline values (Δ‰) per 100 mg caffeine.

参考文章(38)
Shyu Jk, Wang Yj, Lo Kj, Lee Sd, Lu Rh, Caffeine clearance test: a quantitative liver function assessment in patients with liver cirrhosis. National Medical Journal of China. ,vol. 57, pp. 329- 334 ,(1996)
William D. Parsons, Allen H. Neims, Effect of smoking on caffeine clearance Clinical Pharmacology & Therapeutics. ,vol. 24, pp. 40- 45 ,(1978) , 10.1002/CPT197824140
Charles Gardner Child, The liver and portal hypertension Saunders. ,(1964)
M. J. Arnaud, C. Welsch, Theophylline and caffeine metabolism in man Vieweg+Teubner Verlag, Wiesbaden. pp. 135- 148 ,(1982) , 10.1007/978-3-663-05268-5_18
G. C. Farrell, W. G. E. Cooksley, L. W. Powell, Drug metabolism in liver disease: Activity of hepatic microsomal metabolizing enzymes Clinical Pharmacology & Therapeutics. ,vol. 26, pp. 483- 492 ,(1979) , 10.1002/CPT1979264483
Gordon J.-H. Park, Elke Wiseman, Jacob George, Peter H. Katelaris, Francis Seow, Caroline Fung, Meng C. Ngu, Non-invasive Estimation of Liver Fibrosis in Non-alcoholic Fatty Liver Disease Using the 13C-Caffeine Breath Test Journal of Gastroenterology and Hepatology. ,vol. 26, pp. no- no ,(2011) , 10.1111/J.1440-1746.2011.06760.X
Frederick W. Lewis, William G. Rector, Caffeine clearance in cirrhosis: The value of simplified determinations of liver metabolic capacity Journal of Hepatology. ,vol. 14, pp. 157- 162 ,(1992) , 10.1016/0168-8278(92)90152-F
K. Vistisen, S. Loft, H. E. Poulsen, Cytochrome P450 IA2 Activity in Man Measured by Caffeine Metabolism: Effect of Smoking, Broccoli and Exercise Advances in Experimental Medicine and Biology. ,vol. 283, pp. 407- 411 ,(1991) , 10.1007/978-1-4684-5877-0_55