Changes in intestinal cell proliferation, absorptive capacity and structure in young, adult and old rats.

摘要: Intestinal epithelial morphology, crypt cell production and absorptive function were investigated in 9 groups of rats, aged from 3 to 121 weeks. Absorption per unit length intestine peaked the first weeks life this was associated with increased villus size, absorption mg tissue weight. gut continued increase throughout life, which could be attributed a similar intestinal weight cm, despite decreased adult animals. Crypt-villus ratio rapidly between 6 8 weeks, but then appeared reach plateau. Crypt started off at high rate all sites young adult. While there some evidence for small, non-significant, proliferation very old no marked elevation reported by workers.