Effect of Lactobacillus-fermented diets on bacterial translocation and intestinal flora in experimental prehepatic portal hypertension.
作者： R Wiest , F Chen , G Cadelina , RJ Groszmann , G Garcia-Tsao
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摘要: Spontaneous bacterial infections in cirrhosis and portal hypertension have been attributed to trans- location of gut-derived bacteria, a process promoted by intestinal overgrowth disruption the gut mucosal barrier. Bacteriotherapy with Lactobacillus has reported correct overgrowth, stabilize barrier function, decrease translocation rat models acute liver injury failure. In this study we investigated effect Lactobacillus-supplemented diets on flora rate vein ligated rats. Lactobacillus-fermented milk (yogurt) containing at least 2 × 109 colony forming units/ml or placebo (water) was adminstrated gavage twice daily (2 ml) for 9 days. Portal ligation performed day 7 treatment. Bacterial mesenteric lymph nodes quantification assessed standard bacteriological cultures. not significantly different between animals that received yogurt (82%) those (75%). Yogurt did induce any significant changes flora, whether it produced acidophilus GG. conclusion, prehepatic hypertension, bacteriotherapy unable probably because flora.
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