摘要: Although 1–4-dihydropyrines (DHP), stable intermediates of the synthesis pyridine by Hantzsch reaction, have been produced since late nineteenth century, their biological activity remained for a long time uninvestigated. In 1949, Phillips at Wellcome laboratories in United States synthetized DHPs and tested them possible analgesic curare-like effects [1], he evaluated derivatives now known to possess potent calcium-antagonistic properties — his compound No. I differed from nifedipine merely nonessential shift meta position NO2 substituent thought that actions compounds vivo represented no more than “undesirable side effects” [1].
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