Preservation of endothelium-dependent vascular relaxation in cholesterol-fed rabbit by treatment with the calcium blocker PN 200110.

摘要: We tested the effects of low doses a dihydropyridine calcium antagonist, PN 200110, on endothelium-dependent vascular relaxation in rabbits fed 1% cholesterol diet. The drug was given orally, 1 mg/day, and control received placebo. Plasma total after 10 weeks, similar placebo- 200110-treated groups. respective values averaged 2140 +/- 116 (n = 14; mean SEM) 2012 115 mg/dl 13). In placebo-treated rabbits, sudanophilic aortic lesions covered 52 5% intimal surface, concentration 72 6 mg/g protein. Corresponding aortas from were significantly lower [36 (P less than 0.03) 3 protein 0.03)]. Maximal cholinergic strips untreated 14) treated cholesterol-fed 13) differed 0.01) 31 4% 61 7% value normocholesterolemic controls conclude that feeding suppresses evoked by acetylcholine, 200110 reduces severity atherosclerosis impairment relaxation.