Dietary Restriction and Aging in Rodents: a Current View on its Molecular Mechanisms

作者: Isao Shimokawa , Lucas S Trindade , None

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摘要: Dietary restriction (DR) is a robust non-genetic intervention that reduces morbidity and mortality in range of organisms. This suggests the presence an evolutionary-conserved pathway regulates aging lifespan response to reduced food or energy intake. Recent genetic analyses have shown single gene mutations could extend lifespan, even mammals. Many longevity genes are clustered into nutrient-sensing metabolic adaptation pathways, which also thought be involved effect DR. The responses these mutant animals DR terms other phenotypes suggest proteins encoded by effects review focuses on roles fork head box O (FoxO) transcription factors, AMP-activated protein kinase (AMPK), sirtuins (particularly SIRT1) rodents. FoxO factors mammalian orthologs DAF-16, required for extending insulin-like signaling nematodes. A recent study rodents suggested FoxO1 anti-neoplastic Although aak2 nematodes (mammalian AMPK), Sir2 yeast Sir2.1 were reported essential extension DR, findings depend backgrounds organisms and/or methods used induce In rodents, AMPK SIRT1 implicated regulation long-term Genetic molecular dissection mechanisms underlying will provide us with knowledge basic processes, as well insights development mimetics, healthy humans.

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