Improving the Membrane Permeability of 5-Fluorouracil via Cocrystallization

作者: Xia-Lin Dai , Song Li , Jia-Mei Chen , Tong-Bu Lu

DOI: 10.1021/ACS.CGD.6B00552

关键词:

摘要: … The present study demonstrates that cocrystallization of 5-fluorouracil with lipophilic … Three cocrystals of 5-fluorouracil with 3-hydroxybenzoic acid, 4-aminobenzoic acid, and cinnamic …

参考文章(33)
Adrian C. Williams, Brian W. Barry, Terpenes and the Lipid–Protein–Partitioning Theory of Skin Penetration Enhancement Pharmaceutical Research. ,vol. 8, pp. 17- 24 ,(1991) , 10.1023/A:1015813803205
F. Benaouda, M.B. Brown, B. Shah, G.P. Martin, S.A. Jones, The influence of self-assembling supramolecular structures on the passive membrane transport of ion-paired molecules. International Journal of Pharmaceutics. ,vol. 439, pp. 334- 341 ,(2012) , 10.1016/J.IJPHARM.2012.09.001
Youssef W. Naguib, Amit Kumar, Zhengrong Cui, The effect of microneedles on the skin permeability and antitumor activity of topical 5-fluorouracil Acta Pharmaceutica Sinica B. ,vol. 4, pp. 94- 99 ,(2014) , 10.1016/J.APSB.2013.12.013
Amit Delori, Mark D Eddleston, William Jones, Cocrystals of 5-fluorouracil CrystEngComm. ,vol. 15, pp. 73- 77 ,(2013) , 10.1039/C2CE26147B
Qian Tao, Jia-Mei Chen, Lei Ma, Tong-Bu Lu, Phenazopyridine Cocrystal and Salts That Exhibit Enhanced Solubility and Stability Crystal Growth & Design. ,vol. 12, pp. 3144- 3152 ,(2012) , 10.1021/CG300327X
AV Yadav, AS Shete, AP Dabke, PV Kulkarni, SS Sakhare, None, Co-crystals: a novel approach to modify physicochemical properties of active pharmaceutical ingredients. Indian Journal of Pharmaceutical Sciences. ,vol. 71, pp. 359- 370 ,(2009) , 10.4103/0250-474X.57283
Robhash Kusam Subedi, Seaung Youl Oh, Myung-Kwan Chun, Hoo-Kyun Choi, Recent advances in transdermal drug delivery Archives of Pharmacal Research. ,vol. 33, pp. 339- 351 ,(2010) , 10.1007/S12272-010-0301-7
Yan Yan, Jia-Mei Chen, Tong-Bu Lu, Simultaneously enhancing the solubility and permeability of acyclovir by crystal engineering approach CrystEngComm. ,vol. 15, pp. 6457- 6460 ,(2013) , 10.1039/C3CE41017J
M Iervolino, S.L Raghavan, J Hadgraft, Membrane penetration enhancement of ibuprofen using supersaturation. International Journal of Pharmaceutics. ,vol. 198, pp. 229- 238 ,(2000) , 10.1016/S0378-5173(00)00346-X