Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge. Characterization of eosinophil and mast cell mediators.

摘要: Segmental antigen bronchoprovocation was used to define the nature of inflammatory process in allergic airway disease. Bronchoalveolar lavage fluid obtained from rhinitis patients 12 min after segmental instillation (immediate response) revealed a significant increase histamine and tryptase, but no cellular response. Repeat 48 h later (late showed marked increases both low normal density eosinophils as well striking elevations eosinophil granular protein levels (major basic protein, eosinophil-derived neurotoxin, cationic peroxidase). Leukotriene C4, not concentrations were also consistently elevated late samples. Further, samples interleukin-5 that correlated with presence proteins. Neither nor soluble mediators increased when su...