Pentobarbital inhibition of human recombinant α1A P/Q-type voltage-gated calcium channels involves slow, open channel block
作者： A Schober , E Sokolova , KJ Gingrich
DOI: 10.1111/J.1476-5381.2010.00886.X
关键词:
摘要: BACKGROUND AND PURPOSE Pre-synaptic neurotransmitter release is largely dependent on Ca2+ entry through P/Q-type (CaV2.1) voltage-gated channels (PQCCs) at most mammalian, central, fast synapses. Barbiturates are clinical depressants and inhibit pre-synaptic entry. PQCC barbiturate pharmacology generally unclear, specifically in man. The of the pentobarbital (PB) human recombinant α1A PQCCs has been characterized.
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