Antimicrobial activity of selected non-antibiotics--activity of methotrexate against Staphylococcus aureus strains.

摘要: Some non-antibiotic drugs, e.g. cytostatics, anaesthetics or vasodilators may also show the antimicrobial activity. The aim of this study was to detect and characterise activity expressed by selected drugs analysed during state control performed in Drug Institute. Over 60 were randomly chosen from different groups. surveillance on standard microbial strains: S. aureus ATCC 6538P, E. coli 8739, P. aeruginosa 15442 C. albicans 10231. It found that listed below inhibited growth at least one examined Acesan 0.075 tabl., Benuron 500 mg Chlorchex 0.5 aerosol, Methotrexat-Ebewe amp., Naproxen Nospa Forte Platamine 50 Platidiam Sensit drag., Septofervex 2 Seractil 400 Sermion 4 Sinemet 125 Tarproxen tabl. Zyban 150 interesting, strong methotrexate limited Staphylococcus strain. Minimal inhibitory concentration determined agar dilution method with use 54 clinical strains (MRSA-32 MSSA-22). For MSSA strains, MIC50 MIC90 10 micrograms/ml 20 micrograms/ml, respectively (range: 10-20 micrograms/ml). MRSA 100-> 100 10-<