Neonatal caffeine exposure alters adenosine receptor control of locomotor activity in the developing rat.

摘要: An animal model was developed to approximate the magnitude and brain developmental period of caffeine exposure experienced by human infant receiving for apnea prematurity. Serum levels 5-15 mg/l over 24-hour were achieved administering rat pups a loading dose 20 mg/kg p.o. on day 2, followed 15 days 3-6 life. Locomotor activity, both spontaneous following an acute challenge with D-phenylisopropyl adenosine (an receptor agonist, 10 mumol/kg i.p.) or antagonist, 100 i.p.), measured in 12-to 28-day-old native neonatally exposed caffeine. The stimulatory effect locomotor activity developmentally delayed pups. It is postulated that early some way altered development central control activity.