Adenosinergic modulation of respiratory activity: developmental plasticity induced by perinatal caffeine administration.

摘要: Caffeine is an adenosine receptor antagonist that commonly used in the clinic as a respiratory stimulant to treat apnea of prematurity. A recent clinical study showed newborns treated with caffeine present no neuro-developmental disabilities at 2 years age comparison placebo-treated children [Schmidt, B., Roberts, R.S., Davis, P., Doyle, L.W., Barrington, K.J., Ohlsson, A., Solimano, Tin, W., 2007. Long-term effects therapy for N. Engl. J. Med. 357, 1893-1902]. Although neonatal administration this population associated clear short- and long-term health improvements, consequences treatment on basic homeostatic functions such regulation are unknown. This article reviews evidence indicating modifies control development these changes persist until adulthood. The mechanisms contributing form developmental plasticity unknown but current data indicate treatment, especially during perinatal period, alters adenosinergic neuromodulation system. While human show relatively safe some aspects neural development, results obtained animal studies raise important questions pertaining potential