Platelet-derived Growth Factor: Impact on Physiological and Tumor Angiogenesis
作者： Arne Östman , Christer Betsholtz
DOI: 10.1007/978-3-540-33177-3_9
关键词:
摘要: The PDGF growth factors make up a family of five dimeric acting through the two tyrosine kinase α-and s-receptors. This chapter summarizes findings, predominantly from analyses genetically modified mice, which have established important functions for receptor signaling in recruitment and vascular mural cells. text also reviews studies confirmed roles tumor angiogenesis, involving effects on Thereafter, preclinical demonstrating anti-angiogenic anti-tumoral inhibitors are reviewed. Finally, results clinical using drugs that block PDGF-receptors discussed.
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