A new drug delivery system using plasma-irradiated pharmaceutical aids. VIII. Delayed-release of theophylline from double-compressed tablet composed of eudragit as wall material.
作者： Masayuki KUZUYA , Kousuke ITO , Shin-ichi KONDO , Yoshimitsu MAKITA
DOI: 10.1248/CPB.49.1586
关键词:
摘要: The rapid release from a double-compressed tablet containing theophylline as core drug with the pH-dependent water-soluble polymers, Eudragit L100, S100 or L100-55 used wall material was suppressed by argon plasma-irradiation due to an effect of inter-segmental cross-link reactions on decrease in surface polymer solubility outer layer. In addition, lower glass transition temperature (Tg) has converted into delayed-release system under set plasma operational conditions additional heat flux softening resulting formation film-like particle-particle interlinking
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