Effects of prolonged iron overload and low frequency electromagnetic exposure on spatial learning and memory in the young rat
作者： Christophe Melon , Mohsen Sakly , Hafedh Abdelmelek , Bruno Poucet , Etienne Save
DOI: 10.1016/J.NLM.2009.04.002
关键词:
摘要: Low-frequency electromagnetic fields (EMF) have been suggested to affect the brain via alterations of blood–brain barrier permeability iron. Because an immature barrier, young may be particularly vulnerable EMF exposure. It is therefore possible that behavioral and neurotoxic effects resulting from EMF-induced iron excess in would greater adults. The objective present study was investigate interaction between low-frequency overload rats. In Experiment 1, we tested on spatial learning memory. Iron treatment did not performance a reference (Morris water maze) working memory task (8-arm radial maze). contrast, detection change object exploration impaired. These correlated with modifications serotoninergic metabolism. 2, combination exposure tested. As rats were impaired tasks but mildly change. Overall, results showed effect spontaneous processes. However, potentiate
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sci-hub.se 参考文章(84)
Fabrizio Vecchio, Claudio Babiloni, Florinda Ferreri, Giuseppe Curcio, Rita Fini, Claudio Del Percio, Paolo Maria Rossini, Mobile phone emission modulates interhemispheric functional coupling of EEG alpha rhythms. European Journal of Neuroscience. ,vol. 25, pp. 1908- 1913 ,(2007) , 10.1111/J.1460-9568.2007.05405.X
E ESPOSITO, V DIMATTEO, G DIGIOVANNI, Serotonin–dopamine interaction: an overview Progress in Brain Research. ,vol. 172, pp. 3- 6 ,(2008) , 10.1016/S0079-6123(08)00901-1
Torben Moos, Evan H. Morgan, Transferrin and Transferrin Receptor Function in Brain Barrier Systems Cellular and Molecular Neurobiology. ,vol. 20, pp. 77- 95 ,(2000) , 10.1023/A:1006948027674
V DIMATTEO, G DIGIOVANNI, M PIERUCCI, E ESPOSITO, Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies. Progress in Brain Research. ,vol. 172, pp. 7- 44 ,(2008) , 10.1016/S0079-6123(08)00902-3
Luigi Zecca, Moussa B. H. Youdim, Peter Riederer, James R. Connor, Robert R. Crichton, Iron, brain ageing and neurodegenerative disorders Nature Reviews Neuroscience. ,vol. 5, pp. 863- 873 ,(2004) , 10.1038/NRN1537
S.M. Bawin, W.M. Satmary, R.A. Jones, W.R. Adey, G. Zimmerman, Extremely-low-frequency magnetic fields disrupt rhythmic slow activity in rat hippocampal slices. Bioelectromagnetics. ,vol. 17, pp. 388- 395 ,(1996) , 10.1002/(SICI)1521-186X(1996)17:5<388::AID-BEM6>3.0.CO;2-#
E. Maby, R. Le Bouquin Jeannès, G. Faucon, C. Liégeois-Chauvel, R. De Sèze, Effects of GSM signals on auditory evoked responses Bioelectromagnetics. ,vol. 26, pp. 341- 350 ,(2005) , 10.1002/BEM.20107
Diane Dubreuil, Thérèse Jay, Jean-Marc Edeline, Does head-only exposure to GSM-900 electromagnetic fields affect the performance of rats in spatial learning tasks? Behavioural Brain Research. ,vol. 129, pp. 203- 210 ,(2002) , 10.1016/S0166-4328(01)00344-8
A. Fredriksson, N. Schröder, T. Archer, Neurobehavioural deficits following postnatal iron overload: I spontaneous motor activity. Neurotoxicity Research. ,vol. 5, pp. 53- 76 ,(2003) , 10.1007/BF03033373
Diane Dubreuil, Thérèse Jay, Jean-Marc Edeline, Head-only exposure to GSM 900-MHz electromagnetic fields does not alter rat’s memory in spatial and non-spatial tasks Behavioural Brain Research. ,vol. 145, pp. 51- 61 ,(2003) , 10.1016/S0166-4328(03)00100-1