Stress biomarkers in a rat model of decompression sickness
作者： Richard M. Mccarron , Elizabeth Montcalm-Smith , Ye Chen , James Caviness
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摘要: INTRODUCTION Immune reactivity, stress responses, and inflammatory reactions may all contribute to pathogenic mechanisms associated with decompression sickness (DCS). Currently, there are no biomarkers for DCS. This research examined if DCS is increased levels of vascular function, early/non-specific hypothalamic-pituitary-adrenal (HPA) axis responses. METHODS Rats undergoing a test dive 175 ft seawater (fsw) (6.2 ATA) 60 min rapid were observed (ambulatory deficit). Animals exercised on rotating cage (approximately 3 m x min(-1)) throughout the subsequent 30-min observation period. All animals euthanized blood tissue samples (brain, liver, lung) collected analysis CRP ET-1 by ELISA markers PCR. RESULTS HO-1 HSP-70 in brain, HO-1, Egr-1, iNOS lungs There was difference any marker or serum ET-1. CONCLUSIONS The results demonstrate that < 30 after surfacing, genomic changes compared not showing signs Identification specific permit use such as predictors susceptibility and/or occurrence.
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