Effect of Alstonia scholaris bark extract on testicular function of Wistar rats.

摘要: AIM To evaluate the antifertility effect of Alstonia scholaris bark extract in male rats. METHODS In Wistar rats was given by oral route at a dose 200 mg/day for 60 days. The fertility and testicular function were assessed mating tests, sperm motility, concentration, biochemical indices cell population dynamics. RESULTS Oral feeding with period days did not cause body weight loss, while weights testes, epididymides, seminal vesicle ventral prostate significantly reduced. production step-19 spermatids reduced 79.6% treated preleptotene pachytene spermatocytes decreased 61.9% 60.1%, respectively. Spermatogonia Sertoli also affected. seminiferous tubule Leydig nuclear area (P<0.01) when compared to controls. Reduced count motility resulted total suppression fertility. A significant fall protein sialic acid content as well glycogen testes noticed. fructose lowered whereas cholesterol elevated following compounds obtained from chromatographic separation over Si-gel column: agr-amyrin, bgr-amyrin, lupiol acetate, venenative, rhazine yohimbine. CONCLUSION At level employed, has rats; primary site action may be post meiotic germ cells (Step 19 spermatids).