Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation
作者： P. Chen , B. Fenet , S. Michaud , N. Tomczyk , E. Véricel
DOI: 10.1016/J.FEBSLET.2009.10.004
关键词:
摘要: Our study aimed to establish the complete structure of main dihydroxy conjugated triene issued from lipoxygenation (soybean enzyme) docosahexaenoic acid, named PDX, an isomer protectin/neuroprotectin D1 (PD1/NPD1) described by Bazan and Serhan. NMR approaches other chemical characterization (e.g. GC-MS, HPLC LC-MS/MS) indicated that PDX is 10(S),17(S)-dihydroxy-docosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid. The use (18)O(2) mass spectrometry showed a double product. Its differs PD1, with E,Z,E geometry (PDX) instead E,E,Z (PD1) S configuration at carbon 10 R. inhibits human blood platelet aggregation sub-micromolar concentrations.
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