Evaluation of the relationship between T663A polymorphism in the alpha-epithelial sodium channel gene and essential hypertension

摘要: Objectives: To evaluate the relationship between alpha epithelial sodium channel (alpha-ENaC) T663A polymorphism and risk of essential hypertension. Methods: This meta-analysis was conducted November 2014 February 2015 in Shanghai Medical Instrumentation College, Shanghai, China. We collected all published available case-control data (N=12) identified through PubMed, Web Science, Scopus, Chinese National Knowledge Infrastructure (CNKI) up to December 2014. The pooled odds ratio (OR) with 95% confidence interval (CI) calculated using fixed- or random-effect model. Results:  Although subgroup analysis showed that alpha-ENaC associated hypertension North American individuals (OR=1.55, CI=1.22-1.98, p =0.0003), our results did not confirm such association overall (OR=1.03, CI=0.92-1.15, =0.62). lack further confirmed by non-superiority test ( less than  0.0001). Conclusion: Alpha-ENaC might be a factor for Saudi Med J 2015; Vol. 36 (9): 1039-1045 doi: 10.15537/smj.2015.9.11822