Retinoblastoma gene deletions in human glioblastomas.

摘要: The retinoblastoma susceptibility gene, RB, is the best characterised of tumour suppressor genes, or 'anti-oncogenes'. Abnormal function RB protein thought to result in loss an inhibitory effect on cell growth, and thus contribute towards development certain human cancers. One group cancers particular interest relationship gene are gliomas, which central nervous system tumours originate from neuroectoderm, embryological tissue also gives rise retinoblastomas. We have therefore examined a benign malignant gliomas for evidence structural alterations gene. Four out nine (44%) glioblastomas, most showed heterozygosity locus within this In addition, one these hemizygous deletion part protein-coding region, abnormality was present cells cultured tumour. These findings suggest that abnormalities may glioblastomas.