Genomic changes in glioblastoma cell lines detected by comparative genomic hybridization.
作者： Vijayanagaram S. Venkatraj , Martin Begemann , Antonio Sobrino , Jeffrey N. Bruce , I. Bernard Weinstein
关键词: Virtual karyotype 、 Tumor progression 、 Cytogenetics 、 Gene 、 Glioma 、 Biology 、 Comparative genomic hybridization 、 Genome 、 Genetics 、 DNA
摘要: Comparative genomic hybridization serves as a screening test for regions of copy number changes in tumor genomes. We have applied the technique to map DNA gains and losses 5 cell lines derived from glioblastoma multiforme, most common primary neoplasm central nervous system. The frequent occurred on chromosomes 10 13. were observed 5, 6, 7 20. Some novel sites alterations also observed. Analysis areas loss gain these provides basis future attempts more finely genetic elucidation genes involved progression.
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