Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression.
作者： Louis Dubeau , Mihaela Velicescu , Gerrit D'Ablaing , Timothy M. Kim , Jianping Zheng
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摘要: Abstract We examined the frequencies of loss heterozygosity on chromosome 13 in 77 primary ovarian epithelial tumors subdivided into cystadenomas, low malignant potential, grade carcinomas, and high carcinomas. Such losses were found approximately 50% carcinomas but not detected any other tumor subtypes ( P
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