Treatment of airway hyperreactivity

作者: Dale T. Umetsu , Rosemarie Helena Dekruyff-Umetsu , Everett Hurteau Meyer , Muriel Pichavant , Stephanie Ann Shore

DOI:

关键词:

摘要: The invention provides strategies for treating and preventing airway hyperreactivity non-allergic asthma comprising antagonizing IL-17 activity and/or production by iNKT cells. Provided herein is a method of diagnosing neutrophils quantification in sputum.

参考文章(10)
William C. Fanslow, Melanie K. Spriggs, Zhengbin Yao, Methods of treating allergy by administering interleukin-17 receptor ,(2003)
Scott R. Presnell, Steven K. Burkhead, Zeren Gao, Steven D. Levin, Rolf E. Kuestner, Janine Bilsborough, Stephen R. Jaspers, Soluble zcytor14, anti-zcytor14 antibodies and binding partners and methods of using in inflammation ,(2005)
Marie-Laure Michel, Alexandre Castro Keller, Christophe Paget, Masakazu Fujio, François Trottein, Paul B. Savage, Chi-Huey Wong, Elke Schneider, Michel Dy, Maria C. Leite-de-Moraes, Identification of an IL-17–producing NK1.1neg iNKT cell population involved in airway neutrophilia Journal of Experimental Medicine. ,vol. 204, pp. 995- 1001 ,(2007) , 10.1084/JEM.20061551
A. BARCZYK, W. PIERZCHALA, E. SOZAÑSKA, Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respiratory Medicine. ,vol. 97, pp. 726- 733 ,(2003) , 10.1053/RMED.2003.1507
J Douwes, P Gibson, J Pekkanen, N Pearce, Non-eosinophilic asthma: importance and possible mechanisms Thorax. ,vol. 57, pp. 643- 648 ,(2002) , 10.1136/THORAX.57.7.643
Jonathan Wendell Tetreault, Barrett Allan, Chi-Kin Chow, Andrew Gordon Werner, Kingman Ng, Jirong Lu, Lihua Huang, Ling Liu, Anti-il-17 antibodies ,(2006)
D. S. POSTMA, H. A. M. KERSTJENS, Characteristics of airway hyperresponsiveness in asthma and chronic obstructive pulmonary disease American Journal of Respiratory and Critical Care Medicine. ,vol. 158, ,(1998) , 10.1164/AJRCCM.158.SUPPLEMENT_2.13TAC170
John V. Fahy, Kwang Woo Kim, Jane Liu, Homer A. Boushey, Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation The Journal of Allergy and Clinical Immunology. ,vol. 95, pp. 843- 852 ,(1995) , 10.1016/S0091-6749(95)70128-1
Dominique MA Bullens, Els Truyen, Liesbeth Coteur, Ellen Dilissen, Peter W Hellings, Lieven J Dupont, Jan L Ceuppens, IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? Respiratory Research. ,vol. 7, pp. 135- 135 ,(2006) , 10.1186/1465-9921-7-135
J Monteseirín, Neutrophils and asthma. Journal of Investigational Allergology and Clinical Immunology. ,vol. 19, pp. 340- 354 ,(2009)