Movement disorders of aged rats: reversal by dopamine receptor stimulation

摘要: When placed in a tank of water, aged rats (24 to 27 months old) showed marked impairments swimming. Compared with young adult (3 4 old), the older animals moved their limbs less vigorously and were successful keeping heads above water. The young, but not old, maintained position nearly horizontal water surface planed across it. These movement dysfunctions resemble those seen that have sustained injury brain dopamine-containing neurons. swimming reversed by dopamine receptor stimulant apomorphine biosynthetic precursor dopamine, L-dopa. Thus, age-related alterations dopaminergic systems may be responsible for some disturbances associated senescence.