The Effects of Nicotine on Learning and Memory: A Neuropsychological Assessment inYoung and Senescent Fischer 344 Rats
作者： Cullen M Attaway , David M Compton , Matthew D Turner
DOI: 10.1016/S0031-9384(99)00081-5
关键词: Motor coordination 、 Working memory 、 Psychology 、 Neuroscience 、 Memoria 、 Neurotransmitter 、 Neuropsychological assessment 、 Intraperitoneal injection 、 Morris water navigation task 、 Nicotine 、 Physiology
摘要: The effects of chronic nicotine on the behavioral performance young (4 month) and old (24 Fischer-344 rats were assessed four tasks: activity chamber, rotating rod, serial pattern learning, Morris water maze paradigm. Old nicotine-treated received an intraperitoneal injection (0.20 mg/kg) 15 min prior to all testing, saline-treated saline injections testing. Nicotine improved motor coordination increased general levels compared rats. There no significant differences in behaviors these evaluations. In rats, acquisition a pattern, suggesting improvement working memory or related processes. was found increase swim speed paradigm with hidden platform; however, beneficial reference obtained for either age group. These results suggests that may not be as attenuating age-related learning deficits once proposed.
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