Neuron numbers and dendritic extent in normal aging and Alzheimer's disease

摘要: Abstract Factors which limit the interpretation of studies aging brain include: secular trends, species and strain differences, effects tissue processing, bias may be introduced at many levels an experimental design. With these limitations considered, evidence is reviewed regarding neuron numbers dendritic extent in normally rodent, monkey human Alzheimer's disease. It concluded that loss change normal are regionally specific, corresponding regions do not always similar ways rodents primates. suggested such differences may, part, due to inconsistent definitions ‘aged’ among species. In disease there excess regression some, but all, regions. Measures morphological substrates function show appreciable overlap between AD control groups. hypothesized static, post-mortem status morphology adequately reflect functional capabilities dynamic living brain.