Structural diversity of arthropod venom toxins.
作者： Norelle L. Daly , David Wilson
DOI: 10.1016/J.TOXICON.2018.07.018
关键词:
摘要: Arthropods are a diverse and ancient group of invertebrate animals, which constitute approximately 75-85% all known species on earth. Many arthropod species, such as spiders, scorpions even some crustaceans, contain venoms that can be very complex, representing natural combinatorial libraries bioactive compounds. Characterization the compounds in these has helped development tools for pharmacology, discovery lead molecules therapeutic treatments. A critical aspect characterization venom is determination three-dimensional structure. Structural analysis provide insight into many processes including understanding target interactions developing more potent selective drug leads. Arthropod an extremely rich source novel structures this review provides overview structural diversity, proteins, peptides small molecules.
sci-hub.se 参考文章(111)
Takashi Abe, Masato Sugita, Tsuyoshi Fujikura, Jiro Hiyoshi, Michinori Akasu, Giant hornet (Vespa mandarinia) venomous phospholipases Toxicon. ,vol. 38, pp. 1803- 1816 ,(2000) , 10.1016/S0041-0101(00)00109-4
Tara L. Pukala, Jason R. Doyle, Lyndon E. Llewellyn, Lucia Kuhn-Nentwig, Margit A. Apponyi, Frances Separovic, John H. Bowie, Cupiennin 1a, an antimicrobial peptide from the venom of the neotropical wandering spider Cupiennius salei, also inhibits the formation of nitric oxide by neuronal nitric oxide synthase FEBS Journal. ,vol. 274, pp. 1778- 1784 ,(2007) , 10.1111/J.1742-4658.2007.05726.X
T C Terwilliger, D Eisenberg, The structure of melittin. II. Interpretation of the structure. Journal of Biological Chemistry. ,vol. 257, pp. 6016- 6022 ,(1982) , 10.1016/S0021-9258(20)65098-0
T C Terwilliger, D Eisenberg, The structure of melittin. I. Structure determination and partial refinement. Journal of Biological Chemistry. ,vol. 257, pp. 6010- 6015 ,(1981) , 10.1016/S0021-9258(20)65097-9
Wang XiuHong Wang XiuHong, M Connor, R Smith, MW Maciejewski, MEH Howden, GM Nicholson, MJ Christie, GF King, Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge. Nature Structural & Molecular Biology. ,vol. 7, pp. 505- 513 ,(2000) , 10.1038/75921
David J. Craik, David P. Fairlie, Spiros Liras, David Price, The Future of Peptide-based Drugs Chemical Biology & Drug Design. ,vol. 81, pp. 136- 147 ,(2013) , 10.1111/CBDD.12055
Andreas Brust, Elka Palant, Daniel E. Croker, Barbara Colless, Roger Drinkwater, Brad Patterson, Christina I. Schroeder, David Wilson, Carsten K. Nielsen, Maree T. Smith, Dianne Alewood, Paul F. Alewood, Richard J. Lewis, chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. Journal of Medicinal Chemistry. ,vol. 52, pp. 6991- 7002 ,(2009) , 10.1021/JM9003413
P. Merlin, J. C. Braekman, D. Daloze, J. M. Pasteels, Tetraponerines, toxic alkaloids in the venom of the Neo-Guinean pseudomyrmecine ant Tetraponera sp Journal of Chemical Ecology. ,vol. 14, pp. 517- 527 ,(1988) , 10.1007/BF01013903
Kartik Sunagar, Eivind Undheim, Angelo Chan, Ivan Koludarov, Sergio Muñoz-Gómez, Agostinho Antunes, Bryan Fry, Evolution stings: the origin and diversification of scorpion toxin peptide scaffolds. Toxins. ,vol. 5, pp. 2456- 2487 ,(2013) , 10.3390/TOXINS5122456
Yasuto Todokoro, Ikuko Yumen, Kei Fukushima, Shin-Won Kang, Jang-Su Park, Toshiyuki Kohno, Kaori Wakamatsu, Hideo Akutsu, Toshimichi Fujiwara, Structure of Tightly Membrane-Bound Mastoparan-X, a G-Protein-Activating Peptide, Determined by Solid-State NMR Biophysical Journal. ,vol. 91, pp. 1368- 1379 ,(2006) , 10.1529/BIOPHYSJ.106.082735