Human normal CD5+ B lymphocytes can be induced to differentiate to CD5- B lymphocytes with germinal center cell features.
作者： F Caligaris-Cappio , M Riva , L Tesio , M Schena , G Gaidano
DOI: 10.1182/BLOOD.V73.5.1259.1259
关键词:
摘要: A significant proportion of cord blood CD5+ B cells express the activation molecules CD23, CD25, and transferrin receptor; react with cell-cycle-associated monoclonal antibody (MoAb) Ki67; can be induced to enter S phase cell cycle by interleukin-2 (IL-2), IL-4, or low-molecular-weight B-cell growth factor (Imw-BCGF) and, exposed IL-1 IL-2, acquire features (sIgD-, CD5-, CD10+, CD38+) blasts proliferating in germinal centers secondary follicles. These findings indicate that are preactivated proper microenvironment, may give rise CD5- cells.
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