Culture methods of bone marrow stromal cells and mesenchymal stem cells, and manufacture method of graft cells for central nerve system diseases therapy
作者： Toshimasa Ochiai , Louis Yuge , Yumi Kawahara
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摘要: In a culture method of the present invention, by culturing bone marrow stromal cells or mesenchymal stem under pseudo micro-gravity environment generated multi-axis rotation, having an average cell size smaller than that before are obtained. The thus cultured suitable as graft for central nerve diseases therapy.
lens.org 参考文章(12)
Valerie E Meyers, Majd Zayzafoon, Joanne T Douglas, Jay M McDonald, RhoA and Cytoskeletal Disruption Mediate Reduced Osteoblastogenesis and Enhanced Adipogenesis of Human Mesenchymal Stem Cells in Modeled Microgravity Journal of Bone and Mineral Research. ,vol. 20, pp. 1858- 1866 ,(2005) , 10.1359/JBMR.050611
Louis Yuge, Teruyuki Kajiume, Hidetoshi Tahara, Yumi Kawahara, Chika Umeda, Reiko Yoshimoto, Shu-Liang Wu, Kazuko Yamaoka, Makoto Asashima, Katsuko Kataoka, Toshinori Ide, Microgravity potentiates stem cell proliferation while sustaining the capability of differentiation. Stem Cells and Development. ,vol. 15, pp. 921- 929 ,(2006) , 10.1089/SCD.2006.15.921
Jieli Chen, Yi Li, Lei Wang, Zhenggang Zhang, Dunyue Lu, Mei Lu, Michael Chopp, Therapeutic Benefit of Intravenous Administration of Bone Marrow Stromal Cells After Cerebral Ischemia in Rats Stroke. ,vol. 32, pp. 1005- 1011 ,(2001) , 10.1161/01.STR.32.4.1005
T. Honma, O. Honmou, S. Iihoshi, K. Harada, K. Houkin, H. Hamada, J.D. Kocsis, Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat Experimental Neurology. ,vol. 199, pp. 56- 66 ,(2006) , 10.1016/J.EXPNEUROL.2005.05.004
Kazuhiko Sugiyama, Kazunori Arita, Masahiro Nishimura, Yukio Kato, Kaoru Kurisu, Takahito Okazaki, Takuro Magaki, Masaaki Takeda, Yoshinori Kajiwara, Ryosuke Hanaya, Intravenous administration of bone marrow stromal cells increases survivin and Bcl-2 protein expression and improves sensorimotor function following ischemia in rats Neuroscience Letters. ,vol. 430, pp. 109- 114 ,(2008) , 10.1016/J.NEULET.2007.10.046
Yi Wang, Sheng Chen, Dehua Yang, Wei-dong Le, Stem cell transplantation: a promising therapy for Parkinson's disease. Journal of Neuroimmune Pharmacology. ,vol. 2, pp. 243- 250 ,(2007) , 10.1007/S11481-007-9074-2
Dunyue Lu, Asim Mahmood, Lei Wang, Yi Li, Mei Lu, Michael Chopp, Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome. Neuroreport. ,vol. 12, pp. 559- 563 ,(2001) , 10.1097/00001756-200103050-00025
Majd Zayzafoon, William E. Gathings, Jay M. McDonald, Modeled microgravity inhibits osteogenic differentiation of human mesenchymal stem cells and increases adipogenesis. Endocrinology. ,vol. 145, pp. 2421- 2432 ,(2004) , 10.1210/EN.2003-1156
Jieli Chen, Yi Li, Michael Chopp, Intracerebral transplantation of bone marrow with BDNF after MCAo in rat Neuropharmacology. ,vol. 39, pp. 711- 716 ,(2000) , 10.1016/S0028-3908(00)00006-X
Oh Young Bang, Jin Soo Lee, Phil Hyu Lee, Gwang Lee, Autologous mesenchymal stem cell transplantation in stroke patients. Annals of Neurology. ,vol. 57, pp. 874- 882 ,(2005) , 10.1002/ANA.20501