Serum creatine phosphokinase (CPK) activity in monozygotic twins discordant for schizophrenia: Heritability of serum CPK activity

摘要: Abstract Recent studies with normal monozygotic and dizygotic twins have established that serum creatine phosphokinase (CPK) activity in man is under genetic control (Meltzer, Dorus, Davis, preparation). This of interest because the reports CPK increased many acutely psychotic patients, provided they are studied first days after onset gross symptoms throughout hospitalization. 1–12 The increases range from slightly above 95% upper limits to 50–75 times for each race-sex group. Furthermore, 25%–30% degree relatives patients slight but persistent activity. 2,3,7 These occur significantly more frequently who themselves had (Meltzer Moretti, Prior which some control, we opportunity study discordant schizophrenia. results will be reported here.