In Search of Normality for Vitamin K1: Establishing Age-Dependent Reference Intervals in the Danish Population.

摘要: BACKGROUND A growing body of evidence suggests that vitamin K has beneficial effects on human health, especially cardiovascular and bone health. Vitamin K1 (phylloquinone), the predominant form in blood, is regarded as an indicator status, but to our knowledge no reference intervals (RIs) have been established for K1. METHODS In this population-based study, was measured serum from 3808 Caucasian individuals without diabetes 26 78 years age. The need gender- age-partitioned evaluated using Lahti's method, exclusion criteria were defined obtain healthy a study group possible. excluded subgroups tested differences mean levels. Serum levels quantified in-house newly developed, validated, highly sensitive online SPE-LC-MS/MS method with limit quantitation (LOQ) 0.05 nmol/L. RESULTS interval 0.22 3.95 nmol/L aged 44 years 0.35 3.70 nmol/L 45 78. Similar age-specific K1-triglyceride ratio being 0.20 3.16 0.31 3.44, respectively. No significant difference found between genders. detectable all samples. Individuals known comorbidity significantly lower compared those comorbidity. Current smokers had nonsmokers. CONCLUSION Age-dependent well-defined, population. Lower comorbidity, suggesting association disease status. Further studies are needed determine optimal level.