Signatures of natural selection among lineages and habitats in Oncorhynchus mykiss

摘要: Recent advances in molecular interrogation techniques now allow unprecedented genomic inference about the role of adaptive genetic divergence wild populations. We used high-throughput genotyping to screen a genome-wide panel 276 single nucleotide polymorphisms (SNPs) for economically and culturally important salmonid Oncorhynchus mykiss. Samples included 805 individuals from 11 anadromous resident populations northwestern United States British Columbia, represented two major lineages including paired each life history within drainages lineage. Overall patterns variation affirmed clear distinctions between most instances, isolation by distance them. Evidence divergent selection at eight candidate loci significant landscape correlations, particularly with temperature. High diversity nonsynonymous mutations peptide-binding region histocompatibility complex (MHC) class II (DAB) gene provided signatures balancing selection. Weak signals potential sympatric were revealed genome scans allele frequency comparisons. Our results suggest an immune-related functions present large resource future studies