Chapter 5 Biosynthesis 6. The Role of Polypeptide in the Biosynthesis of Protein-Linked Oligosaccharides

摘要: Publisher Summary This chapter discusses the role of polypeptide in biosynthesis protein-linked oligosaccharides. There is ample evidence demonstrating that glycoconjugates are messengers bearing information important to a number fundamental biological events, and it expected continued study will elucidate new roles for this class biopolymers. has been especially true glycoproteins where three essential elements have identified defining regulating structure oligosaccharides covalently linked proteins. The present discussion focused upon central one these elements, chain itself, its glycosylation. “decoded” during through mechanisms involving protein-protein protein-oligosaccharide interactions between glycosylation processing apparatus host cell nascent glycoprotein. reviews experimental data which supports tenet discuss several hypotheses appeared literature as possible “decoding” mechanisms.