Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells.
作者： Zhong Guan , Xian-ren Wang , Xiao-feng Zhu , Xue-fei Huang , Jie Xu
DOI: 10.1158/0008-5472.CAN-07-1379
关键词:
摘要: Centrosomal Aurora-A (Aur-A) kinase ensures proper spindle assembly and accurate chromosome segregation in mitosis. Overexpression of Aur-A leads to centrosome amplification, aberrant spindle, consequent genetic instability. In the present study, was found be overexpressed laryngeal squamous cell carcinoma (LSCC). Moreover, expression adversely correlated with median survival, further identified as a potential independent factor for disease prognosis. Suppression Aurora activity chemically or genetically led LSCC Hep2 cycle arrest apoptotic death. Importantly, we that increases migration this novel function Akt1 activation. The enhanced induced by overexpression could abrogated either small-molecule inhibitor short interfering RNA. VX-680, selective inhibitor, decreased phosphorylation at Ser(473) inhibited migration, but failed do so constitutive active (myr-Akt1)-overexpressed cells. our data suggested might also contribute radioresistance LSCC. Inhibiting VX-680 p53 potently sensitized cells radiotherapy, leading significant Ectopic Aur-A, however, reduced level rendered more resistant irradiation. Taken together, showed kinase, negative prognostic marker, promotes reduces radiosensitivity cancer
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