The role of novel biomarker HE4 in endometrial cancer: a case control prospective study

摘要: The aim of the study was to explore clinical value serum human epididymis secretory protein E4 (HE4) and CA125 in endometrial carcinoma. From January 2010 April 2012, specimens were collected from consecutive cases carcinoma uterus benign disease (control group). normal is considered less than 35 U/mL. Two HE4 cutoff are considered: 70 pmol/L 150 pmol/L. specificity analysis performed using Mann–Whitney test for series. level statistical significance set at p < 0.05. sensitivity detecting cancer 19.8 %, whereas 59.4 35.6 % cutoff, respectively. Thus 100 (positive predictive = negative 71.52 61.31 considering two respectively), 62.14 33.9 44.14 %) detection cancer. Combining HE4, detect 60.4 34.6 pmol/L, respectively, with a %. may be new tool preoperative evaluation postoperative surveillance patients, positive yields best specificity.