Impairment of the Intrinsic Capability of Th1 Polarization in Irradiated Mice: A Close Look at the Imbalanced Th1/Th2 Response after Irradiation.

摘要: Two major CD4+ T-helper (Th) lineages are Th1 and Th2, well balanced Th1/Th2 responses essential for immune function. In previously published studies, it was reported that radiation induces a imbalance toward Th2-dominant direction, this may contribute to postirradiation dysfunction. The polarization of Th cells is driven by the cytokine milieu controlled intracellular regulatory pathways respond signaling. It widely accepted aberration, however, precise alterations cytokines in various tissue environments have been difficult evaluate. addition, effects on intrinsic functions remain uncharacterized. Therefore, how affects balance remains somewhat unclear. To address this, we investigated changes capability isolating them from mice exposed assessing an establish...