Increased immunoglobulin binding to cerebral endothelium in patients with antiphospholipid antibodies.
作者： D C Hess , J C Sheppard , R J Adams
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摘要: There is a strong link between antiphospholipid antibodies and stroke. The mechanism of action unknown. Most theories pathogenesis center around platelet or endothelial cell dysfunction. Our aim was to determine if there were immunoglobulins in the sera patients with that bind human brain microvascular cells.We studied from three groups subjects: stroke (group 1), healthy control subjects 2), but without 3). We isolated cells temporal lobectomy specimens used cellular enzyme-linked immunosorbent assay (ELISA) measure immunoglobulin binding derived umbilical vein. chromium release cytotoxicity.Patients had significantly higher immunoglo...
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