A systematic review of pediatric clinical trials of high dose vitamin D

摘要: Background. Due to inadequate UV exposure, intake of small quantities vitamin D is recommended prevent musculoskeletal disease. Both basic science and observational literature strongly suggest that higher doses may benefit specific populations have non-musculoskeletal roles. Evaluating the evidence surrounding high dose supplementation can be challenging given a relatively large growing body clinical trial spanning time, geography, dosing regimens. Study objectives were identify summarize literature, recognize areas with quality evidence, develop resource database makes more immediately accessible end users. Methods. Medline (1946 January 2015), Embase (1974 Cochrane databases (January searched for trials. All pediatric (0-18 years) trials administering than 400 IU (<1 year) or 600 (≥1 included. Data was extracted independently by two authors. An online searchable developed containing relevant information (http://www.cheori.org/en/pedvitaminddatabaseOverview). Sensitivity utility assessed comparing in those from systematic reviews including children. Results. A total 2,579 candidate papers identified, yielding 169 having one arms meeting eligibility criteria. The publication rate has increased significantly 1 per year (1970-1979) 14 (2010-2015). Although 84% focused on healthy children known risk (e.g., renal, prematurity), this proportion declined recent years due rise evaluating outcomes not directly related actions (27% 2010s). Beyond children, only 50 participants low bias clinically outcome prematurity respiratory illness. Finally, we created validated using 13 reviews. Of 38 identified review, 36 (94.7%) could found within database. When compared search strategy reported each use reduced number full assess 85.2% (±13.4%). Conclusion. field highly active, significant increase non-classical diseases outcomes. Despite overall there are few sufficient size provide answers efficacy high-dose D. open access data should assist users rapid comprehensive identification evaluation their population question interest.