Experimental determination of the linear biphasic constitutive coefficients of human fetal proximal femoral chondroepiphysis

摘要: Abstract The mechanical properties of the cartilaginous regions proximal femoral epiphysis are an important factor in load transmission through hip joint young children. Cylindrical test specimens excised from chondroepiphysis human stillborn heads were subjected to uniaxial loading peripherally-unconfined compression, using a ramp/plateau input strain history. corresponding vs time curves analyzed terms recent analytical solution for linear biphasic material (the well-known KLM model), allowing calculation that model's three fundamental constitutive coefficients (permeability, equilibrium modulus and solid-phase Poisson ratio) this material. numerical algorithm developed evaluate yielded very precise replication previously published parametric plots. When fitted experimental histories, however, model provided only rather loose approximation specimen behavior, due apparently substantial underestimation transient response component associated with interstitial fluid transport. Averaged over series, best-fit values permeability (2.51 × 10 −15 m 4 N s −1 ) (0.699 M Pa) range accepted adult articular cartilage. A consequence coarseness curve fits was ratio 0.0 inferred all specimens. exhibited nearly ( r = 0.74) inverse relationship similar reported