Mechanobiology of tendon adaptation to compressive loading through fibrocartilaginous metaplasia.

摘要: Tendons that wrap around bones often undergo fibrocartilaginous metaplasia. In this paper, we examine the biomechanical causes and consequences of We propose an adaptation rule in which tissue permeability changes response to local cyclic hydrostatic pressures associated with physical activity. The proposed predicts development a low-permeability region corresponding representative wrap-around tendon. A poroelastic finite element model is used time-dependent fluid compressive stresses strains solid constituents tendon's extrafibrillar matrix. low adapted maintains pressures, protecting extracellular matrix from high could disrupt organization. Adaptation through metaplasia therefore allows tendons function effectively over lifetime without sustaining excessive mechanical damage due loading.