Protein metabolism and homeostasis in aging

摘要: 1. Synthesis, Modification and Turnover of Proteins during Aging Suresh I.S. Rattan Abstract Introduction Efficiency Accuracy Protein Synthesis Altered Post?Translational Modifications Conclusion 2. Regulation mRNA Translation as a Conserved Mechanism Longevity Control Ranjana Mehta, Devon Chandler?Brown, Fresnida J. Ramos, Lara S. Shamieh Matt Kaeberlein Genome Scale Screens in Yeast Nematodes is Public Determinant Is DR Mediated by Reduced Translation? Possible Mechanisms for How Influences Does Modulate Mammals? 3. the Antagonistic Pleiotropy Hypothesis Pankaj Kapahi Evolution Insulin?Like Signaling (ILS) TOR Pathway Direct to Identify Genes That Antagonistically Regulate Growth Dietary Restriction (DR), Lifespan Extension Inhibition 4. Proteasome Function Determines Cellular Homeostasis Rate Niki Chondrogianni Efstathios Gonos Aging: Which Are Key Players? An Biology Activation: There Way Restore Function? 5. Autophagy Longevity: Lessons from C. elegans Kailiang Jia Beth Levine DAF?2 Insulin/IGF?1?Like Mitochondrial Activity Pathways 6. Progeria Models Guillermo Marino, Alvaro F. Fernandez Carlos Lopez?Otin Physiological Premature 7. ProteinTurnover Tibor Vellai Krisztina Takacs?Vellai Metabolism Promote Interactions between Molecular Involved Degradation 8. Caenorhabditis Geert Depuydt, Jacques R. Vanfleteren Bart P. Braeckman Restriction, Extends Initiation A Model Induced HSF?1 Defense against Proteotoxicity 9. Quality Systems Disease Karin Luce, Andrea Weil Heinz D. Osiewacz Chaperones Necessary Regulated PQC Role Proteases Maintaining Functions Membrane?Bound AAA on Diseases, Apoptosis Lon Protease 10. p38MAPK Senescence Human Murine Fibroblasts Florence Debacq?Chainiaux, Emmanuelle Boilan, Jeremie Dedessus Le Moutier, Geoffroy Weemaels Olivier Toussaint Hardest Word Say The DNA Damage Checkpoint Signal Transduction Gene Expression SIPS: Central TGF?b1 H2O2? UVB?Induced SIPS p38MAPK, p53 Rb Caveolin?1 Interplay with an Anti?Oncogenic Mediating Ras?Induced Senescence- Tumor Suppressing Conclusion: Next Steps 11. Age?Related Conformational Elise A. Kikis, Tali Gidalevitz Richard I. Morimoto Folding