FOXP3+CD4+CD25+ Adaptive Regulatory T Cells Express Cyclooxygenase-2 and Suppress Effector T Cells by a Prostaglandin E2-Dependent Mechanism
作者： Milada Mahic , Sheraz Yaqub , C. Christian Johansson , Kjetil Taskén , Einar M. Aandahl
DOI: 10.4049/JIMMUNOL.177.1.246
关键词:
摘要: CD4+CD25+ regulatory T (T(R)) cells suppress effector by partly unknown mechanisms. In this study, we describe a population of human suppressive adaptive T(R) (T(R)(adapt)) induced in vitro that express cyclooxygenase 2 (COX-2) and the transcription factor FOXP3. T(R)(adapt) produce PGE(2) cell responses manner is reversed COX inhibitors receptor-specific antagonists. resting CD4+CD25- cells, treatment with FOXP3 expression. Thus, autocrine paracrine effects produced COX-2-positive may be responsible for both FOXP3+ phenotype mechanism used these to cells.
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