Effect of cyproheptadine administration on insulin secretion in acromegalic, diabetic and normal subjects.

摘要: The effect of cyproheptadine (Cypro) and Placebo administration on insulin secretion glucose utilization following i.v. (IVGTT) was evaluated in 8 normal, 7 diabetic acromegalic subjects. Five the subjects had overt diabetes two "chemical" (oral GTT). One diabetes, while one borderline tolerance six normal Cypro increased but not or Methysergide (Methyl) Methy both same None three groups a modification administration. Neither Placebo, altered rate contant (KG). There no change half life tissue sensitivity to from (normal subjects) Despite their increase response serotonin antagonists, have urinary 5-hydroxyindoleacetic acid excretion serum concentrations. Their cannot therefore be attributed generalized overproduction serotonin.