Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review)

作者: James A. McCubrey , William L. Blalock , John G. Shelton , Linda S. Steelman , Richard Franklin

DOI: 10.3892/IJO.22.3.469

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摘要: The Ras/Raf/MEK/ERK signal transduction pathway regulates cell cycle progression and apoptosis in diverse types of cells. Mutations this are often observed transformed lines frequently linked with human cancers. can induce events both associated proliferation arrest. particular course chosen may depend on the strength Raf gene activated by Ras. This also is involved maintaining survival modulating activity apoptotic molecules including Bad Bcl-2. review will discuss regulation how it modulates survival.

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